HORDB

ID: hor005163
Uniprot ID: P09472
Protein name: Gastrin-releasing peptide
Gene name: grp
Organism: Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Family: Bombesin/neuromedin-B/ranatensin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Scyliorhinus (genus), Scyliorhinidae (family), Carcharhiniformes (order), Galeoidea (superorder), Galeomorphii, Selachii (infraclass), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0090277 positive regulation of peptide hormone secretion; GO:1900738 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0031410 cytoplasmic vesicle; GO:0034774 secretory granule lumen

Function: Stimulates the release of gastrin and other gastrointestinal hormones.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P09472-F1.pdb

hor005163_AF2.pdb

hor005163_ESM.pdb

Mass:	320946	Formula:	C126H186N36O32S2
Absent amino acids:	CDITY	Common amino acids:	GP
pI:	9.7	Basic residues:	4
Polar residues:	6	Hydrophobic residues:	8
Hydrophobicity:	-34.4	Boman Index:	-2315
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	46.8
Instability Index:	3346.8	Extinction Coefficient cystines:	5500
Absorbance 280nm:	229.17

PubMed ID: 3436516
Title: Gastrin-releasing peptide from the intestine of the elasmobranch fish, Scyliorhinus canicula (common dogfish).